Not a chance- there's just way, way too many copies of most of these floating around for them to just vanish. Even assuming that more & more end up in the hands of permanent collectors, other factors will see them back on the market, including: financial hardship, downsizing, lifestyle changes, spousal pressure, theft, and death of owner. Yes, that did get morbid- but it's true. I even have a friend who laments having both Felix the Cat & Flinstones Dinosaur Peak as a kid, but lost them as her grandmother had the games. She was out of state when she passed, & her mom had no idea her greedy cousins had run off with the valuables from Grandma's until she called asking why half her games weren't in the box sent to her. I guarantee those people didn't keep them!
So yeah- prices are hardly set in stone, but availability isn't likely to change anytime soon.