Having a hand picked collection of the finest titles would be pretty dope, but I'd probably wind up building the same collection over again, albeit slower given how things are these days.
My collection is probably worth at least $10k over what it estimated given it doesn't cover accessories, systems, guides, magazines, toys, figures, special editions, etc. And a bunch of the higher priced games didn't give a value (Rule of Rose, Earthworm Jim CD, Steel Battalion, etc). Not to mention the 10 boxes or so of dupes.
If someone offered me cash money for what my collection is worth, market value, I'd think about it, but I'd probably turn it down. Too much of what I have would be hard for me to reacquire and some games are just going up in value. Now, if the same type of offer came in a years from now, when I've played much of the games I want to play, I'd probably do it.