Mega Man X: I didn't own a copy of it until about a year or so after it got released. So, whenever I was at a friend's house who happened to have it, we would pop it in and I'd watch him play. When I got my copy, I already knew what I was doing. I mean, there were still some growing pains like the giant spider boss, but all in all it was pretty simple for a MM title.
SotN: Hmm...for one handed play I would say it would be really tricky. Maybe if you started with a cheat code that let you have access to good weapons or armor? It may take away certain challenging aspects of it, but it would also let you get to experience the game. It's fantastic.