Cool idea! Mine might be a tough one. This one was from a top down view and you played as a cockroach or some similar kind of insect. It was basically an action/puzzle hybrid as you had to make your way through some kind of dirty garbage heap. The setting was really dark and creepy, the graphics were pretty realistic for its time (early to mid 90ies), the background music consisted of primitive dark ambient/noise, like Fallout but even more stripped down. Scenes I remember: rummaging through a crushed/bloody dead rat, the first boss fight was a spider you had to lure into a lit cigarette butt to kill. As a kid this game royally freaked me out and I couldn't sleep afterwards. Now I still think about it sometimes as it was a pretty interesting and unique concept. I don't know the exact format but I'm 100% sure it was a PC type, either DOS/early Windows or Amiga.
Never heard about this game again so I don't think it was popular at all.