Best
Resident Evil 2 Remake. The greatest remake ever, maybe? This game feels like a total thesis on how learn the right lessons from your previous games and combine them to make a greater whole.
Worst
Resident Evil 6. The exact opposite. They learned all the wrong lessons and put them into this game.
While RE6 is a bad RE in the traditional sense it makes for a fantastic Co-op action game - Arguably the best we've had in years. Also the RE6 Mercenaries mode is brilliant arcade fun. Yes the story is bombastic but I've certainly had a lot of fun playing it with friends over the years.
I agree with you on the RE2 Remake, though was VERY impressed with RE7 this gen, looking forward to seeing where they go with 8.
Resident Evil
BEST - RE2R (Brilliant re-imagining with tense 3d person combat and dark atmosphere)
WORST - RE Zero ( I liked the opening train section but that was it. Found the character switching mechanic beyond tedious - wish it was co-op like Outbreak)
REmake 2 is so good! I was honestly surprised I picked it over 4, but that one is starting to show its age around the edges, so I just had to chose it.
And I can totally understand picking Zero over 6. Something about 6 has just never sat quite right with me.
BestMega Man 2 is kind of the perfect sequel. It learned a ton of lessons of the previous game and refined the gameplay a ton. While certain things aren't balanced (Metal Blade), the game is basically modular in that you can create your own difficulty at any time with weapon choice, boss order, etc. The biggest flaw in the game is the wall boss, where it becomes possible to soft lock yourself if you run out of the Crash Bombs.
WorstOh man this is tough. Gonna have to go with
Mega Man 7