Since you guys mentioned most of the good stuff so far, I'll say that the Deus Ex: Human Revolution DC is actually pretty good and utilizes the Gamepad to a great degree, and that Wonderful 101 is also pretty fun despite the framerate issues. Xenoblade Chronicles X has also been getting alot of great reviews; still need to pick that up.
Letdowns: Devil's Third
Tank! Tank! Tank!- No idea why this terrible game got a physical home version , and a reprint as well.