Here's my general thoughts:
Fire Emblem Three whatever: I know the series does have its fans, but I don't really care for it.
Advance Wars: Interesting, but I'll have to play it before I'm sure I like the series
No Man's Sky: Don't really care. I remember it being announced like six year ago and finding it interesting... then it came out.
Mario Strikers Battle League: Can't wait! But I'll have to try the Wii version first.
Splatoon 3: Nintendo finally convinced me to give it a try.
Front Mission 1st: At first I thought it was Cyberpunk 2077. It's fine, I guess.
Disney Speedway: They did not show Lightning McQueen for some reason. I will be so mad if he's not in it.
Star Wars: The Force Unleashed: I own it on 360, so I definitely won't be picking it up.
Assassin's Creed Ezio collection: Let's hope it doesn't require a download if you buy it physically!
SD Gundam Battle Alliance: Wasn't this the rarest game for some console?
Chrono Cross: Would've vastly preferred Chrono Trigger first, or the two as a bundle. The addition of a Satellaview game was epic!
Kirby and the Forgotten Land: Can't wait!
MLB the show 22: Do not care.
Kingdom Hearts Cloud versions: Because 20 year old games are too weak for a modern console. Makes sense. I know these games are great, but I'd rather own the PS2 versions.
Klonoa: I'm SO HYPED! The originals cost a fortune secondhand now!
Portal Companion: LETS GOOOOOOOOOO
Live a Live: Thought this was Triangle Strategy. Looks interesting, but I don't think I'll play it.
Nintendo Switch Sports: At first I thought WHY NO MIIS? And then I saw they are in the game. Good on ya Nintendo!
Taiko no Tatsujin: I don't get why we have to subscribe for a song library instead of just buying them individually like for the Rock Band games.
Triangle Strategy: I'm not inclined to buy it.
Cuphead DLC: Nice addition!
Metroid Dread: God Mode and Hardcore mode look fun for those wanting it, but I haven't played Dread yet.
Earthbound/beginnings: YO LET"S GOOOOOOOOOOOOOOOOOOOOO!!!!!! (While Mother 3 would've been nice, these two alone show that Nintendo listens occasionally!)
Zombie Army 4/GetsuFumaDen/Demon Slayer/Lego Brawls/ Two Point Campus: I can't wait for Lego Brawls, but don't much care for the others.
Mario Kart DLC: Good content... FOR A REASONABLE PRICE? I'm shocked...
Xenoblade Chronicles 3: Don't care much for this series, but nice regardless.
All in all, a great direct! I'd give it an A-.