I don't see it dying completely. Video games are a huge defining characteristic for Generation Y (and the later years of Generation X). There will be a nostalgia factor there until we're all dead and gone. Collecting might slow down, but I highly doubt it will ever die off completely. Video games are a massive entertainment empire now. As long as we have video games being made there will be new blood brought into collecting. The numbers will more than likely dwindle as time moves on, as those interested in playing the older titles grow up in a world without physical media. As far as in the next 2 years? No.
Most collectors are between the age of 25 & 35 that I've met (getting to the point where they have some disposable income). I think this is the key factor when it comes to looking to the future of collecting. You have the SMS/NES collectors (those who grew up with the systems as their primary) that are now between the ages of ~ 30-35+, the 25-30 age range out looking for SNES/Gen nostalgia, and the 20-25 year olds looking for N64 & PS1 stuff. My ages might be a little off but I think you can see the picture I'm trying to draw. I realize that most of us on this site are collecting across platforms and generations, but not everyone does this. The biggest price divergence at the moment seems to be in the SNES world, where games have basically doubled or tripled in price over the past year or so. The same thing was going on in the NES world several years ago. We'll see the same thing going on with the N64 & PS1 libraries soon enough.
I think another system that is about to see a hefty price bump is the GBA. Consider this: if you're favorite system is the SNES (which seems to be the retro system in the highest demand at the moment), you're more than likely going to like the offerings from the GBA library. At the same time, you're going to have collectors that grew up with the GBA as their primary handheld coming into the marketplace. (we're going to have an overlap in interest). Thus, a price spike in GBA games. I don't think GBA titles will get totally out of control, but I think they will be inflated for a year or so while the overlapping interest drives up demand.