What kind of mouse are you using? If it's a plain one, might wanna spend the extra $$ for a more ergonomic one and see if it helps. If you're already using one of those, see if maybe a trackball would work better for you.
And playing Diablo would probably be a bad idea.
I have a regular ps2 mouse. I found the keyboard to be more comfortable for Wolfenstein. My right hand to use the arrow keys for movement, and my left hand to use the left side of the keyboard for actions (fire, open, strafe, etc).
Is there a more comfortable mouse and keyboard for the Windows 9x that you would recommend?
And per Diablo, I found out that it will install on my laptop which has Windows 8 on it. And I may try to set up my 360 controller as the mouse as well which would be more comfortable to me.
Do you know if the first Diablo can be played with a Gamepad or probably not huh?